To look only at a few of the most striking contrasts with Oxford’s orthography, take:
vi. ck for k after n.
In Hand D, we find banck and thanck. This pattern strongly survives in the Quartos and poems, with the proportion of -nck to -nk spellings being 140:995. Vnckle (22), nunckle (10), banckrout, inckie, wrinckle, twinckled, ranckle, prancks. In Oxford? Not once in 82 instances. Vncle (5); thank in all its forms (22); think (47).
vii. c and t interchangeable, before ion, -ient, -ial, etc.
In More, we find adicion, infeccion, transportacion (3:5). Perversely, in 200 instances, Oxford never once spells a -tion word with a -cion. Indeed, he so favors t over c, that he often spells words like iuditiall and malitious with it. He has Venetian, auncient, patience; Shakespeare’s Venecian, antient, pacience, and many like spellings survive in the Quartos. xx. ea for e. In the Addition, Shakespeare always (seven times) writes sealf/sealves/sealues/himsealf. “Sealfe-slaughter,” it seems, must have been in the Hamlet foul papers, because the typesetter rendered what he saw as “seale slaughter.” Oxford always (151 times) has self/selfe/selfwill/selues. i. Doubled final consonant (generally after a short vowel). Vppon appears three times in the Hand D Addirion, and is very frequent in the Good Quartos (39:477). Oxford never doubles that p, but always writes vpon or vpone (85:12)